The Use of Cannabidiol in Cutaneous Wound Healing: A Systematic Review.

França J.; de Melo Freitas R.; Rosendo G.; Carvalho M.; de Oliveira G.; Dos Santos J.; Tenorio F.; da Silva J. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026

**Background & Methods** This qualitative systematic review evaluated the efficacy of cannabidiol (CBD), a non-psychoactive Cannabis sativa derivative, in cutaneous wound healing. The review followed PRISMA guidelines and searched seven databases (PubMed, EMBASE, Web of Science, Scopus, Cochrane Library, LILACS, MEDLINE) without publication date restrictions, ultimately analyzing six in vivo studies and clinical trials with bias assessment using RoB 2 and SYRCLE tools. **Key Findings** • Four of five included studies demonstrated beneficial effects of CBD on wound healing, including accelerated wound closure, enhanced collagen deposition, and stimulation of angiogenesis, alongside reduced inflammatory markers and improved histological and biochemical parameters of tissue repair. • CBD promoted fibroblast migration and decreased oxidative stress, suggesting multiple mechanistic pathways supporting tissue regeneration through the compound's known anti-inflammatory and antioxidant properties. • Results were heterogeneous across studies, with one study reporting no significant differences compared to controls, indicating variable efficacy and highlighting the need for standardized protocols. **Dosage & Administration** Not reported. The systematic review did not specify doses, routes of administration, treatment duration, or application methods used across the included studies. **Safety & Adverse Effects** Not reported. The abstract and review did not document adverse effects, tolerability profiles, or safety concerns associated with CBD use in wound healing applications. **Evidence Quality** The current evidence base is limited and represents a low-to-moderate level of evidence. Of 190 identified studies, only six met inclusion criteria, indicating substantial heterogeneity and narrow evidence scope. Study quality assessment was performed using appropriate tools (RoB 2 and SYRCLE); however, the small number of included studies, inconsistent results (one null finding), and predominance of preclinical in vivo models rather than robust clinical trials limit the strength of conclusions. The authors explicitly state that more rigorous, adequately powered clinical studies with standardized methodologies are required before cannabidiol can be recommended for clinical wound healing applications. Systematic review limitations include potential publication bias, variable study designs, and insufficient data for meta-analysis.

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